Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)] calcitonin gene-related peptide and CGRP8–37
نویسندگان
چکیده
Tomoyuki Kawase, Kazuhiro Okuda, and Douglas M. Burns Division of Cellular Pharmacology, Department of Signal Transduction Research, and Division of Periodontology, Department of Oral Biological Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan; and Medical Research Service, Kansas City Department of Veterans Affairs Medical Center, and Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, Missouri
منابع مشابه
Immature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that differentially respond to [Cys(Acm)]-CGRP and CGRP8-37
Address all correspondence to: Tomoyuki Kawase, D.D.S., Ph.D., Division of Cellular Pharmacolgy, Department of Signal Transduction Research, Graduate School of Medical and Dental Sciences, Niigata University 2-5274 Gakkocho-dori, Niigata 951-8514, Japan Phone/Fax +81-25-227-2927 [email protected] Articles in PresS. Am J Physiol Cell Physiol (June 15, 2005). doi:10.1152/ajpcell.00504.2004
متن کاملImmature osteoblastic MG63 cells possess two calcitonin gene-related peptide receptor subtypes that respond differently to [Cys(Acm)(2,7)] calcitonin gene-related peptide and CGRP(8-37).
Calcitonin gene-related peptide (CGRP) is clearly an anabolic factor in skeletal tissue, but the distribution of CGRP receptor (CGRPR) subtypes in osteoblastic cells is poorly understood. We previously demonstrated that the CGRPR expressed in osteoblastic MG63 cells does not match exactly the known characteristics of the classic subtype 1 receptor (CGRPR1). The aim of the present study was to f...
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Calcitonin gene-related peptide (CGRP) is an endogenous vasodilator peptide that produces its effects by activation of CGRP1 and CGRP2 receptor subtypes. These receptor subtypes are characterized in functional studies using the agonist Cys(Acm)2, 7-human-alpha-calcitonin gene-related peptide (Cys(ACM)2, 7-h-alpha-CGRP), which activates CGRP2 receptors, and the antagonist h-alphaCGRP(8-37) which...
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تاریخ انتشار 2005